Drug interactions
Cefpodoxime + Digoxin
Severity: Minor
Cefpodoxime and Digoxin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibiotics that disrupt gut flora can raise digoxin levels in patients whose digoxin is partly inactivated by intestinal bacteria such as Eggerthella lenta. For cefpodoxime this is a theoretical effect and is probably small.
What this interaction means in plain words
Cefpodoxime and Digoxin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cefpodoxime belongs to Anti Bacterial; Digoxin belongs to Cardiovascular.
Why it happens
Possible reduced bacterial inactivation of digoxin in the gut, increasing its absorbed amount.
What to do
Watch for digoxin toxicity symptoms and consider checking digoxin level if the patient is on a narrow margin or develops nausea or arrhythmia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cefpodoxime
- Aluminum hydroxide + Cefpodoxime Moderate
- Amikacin + Cefpodoxime Moderate
- Calcium carbonate + Cefpodoxime Moderate
- Calcium + Cefpodoxime Moderate
- Cefpodoxime + Cholera vaccine Moderate
- Cefpodoxime + Cimetidine Moderate
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Cefpodoxime with Digoxin?
MediHelp rates the interaction as minor. Cefpodoxime and Digoxin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antibiotics that disrupt gut flora can raise digoxin levels in patients whose digoxin is partly inactivated by intestinal bacteria such as Eggerthella lenta. For cefpodoxime this is a theoretical effect and is probably small.
How serious is the interaction between Cefpodoxime and Digoxin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for digoxin toxicity symptoms and consider checking digoxin level if the patient is on a narrow margin or develops nausea or arrhythmia.
What other medicines interact with Cefpodoxime?
MediHelp also lists interactions of Cefpodoxime with, for example, Aluminum hydroxide, Amikacin, Calcium carbonate. The full list is on the Cefpodoxime page.
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