Drug interactions
Cefpodoxime + Esomeprazole
Severity: Moderate
Cefpodoxime and Esomeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cefpodoxime proxetil needs gastric acid for dissolution and absorption. Acid suppression reduces its bioavailability, which may lead to treatment failure.
What this interaction means in plain words
Cefpodoxime and Esomeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefpodoxime belongs to Anti Bacterial; Esomeprazole belongs to Gastrointestinal Tract.
Why it happens
Higher gastric pH reduces the dissolution and absorption of cefpodoxime proxetil.
What to do
Avoid the combination if possible and choose an antibiotic that is not acid-dependent. If used, give cefpodoxime with food and monitor the clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esomeprazole
- Esomeprazole + Mavacamten Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Esomeprazole Major
- Atazanavir + Esomeprazole Major
- Citalopram + Esomeprazole Major
- Clopidogrel + Esomeprazole Major
Other interactions of Cefpodoxime
- Aluminum hydroxide + Cefpodoxime Moderate
- Amikacin + Cefpodoxime Moderate
- Calcium carbonate + Cefpodoxime Moderate
- Calcium + Cefpodoxime Moderate
- Cefpodoxime + Cholera vaccine Moderate
- Cefpodoxime + Cimetidine Moderate
Frequently asked questions
Can I take Cefpodoxime with Esomeprazole?
MediHelp rates the interaction as moderate. Cefpodoxime and Esomeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cefpodoxime proxetil needs gastric acid for dissolution and absorption. Acid suppression reduces its bioavailability, which may lead to treatment failure.
How serious is the interaction between Cefpodoxime and Esomeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible and choose an antibiotic that is not acid-dependent. If used, give cefpodoxime with food and monitor the clinical response.
What other medicines interact with Esomeprazole?
MediHelp also lists interactions of Esomeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Esomeprazole page.
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