Drug interactions
Cefpodoxime + Plazomicin
Severity: Moderate
Cefpodoxime and Plazomicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Plazomicin carries warnings for nephrotoxicity, ototoxicity and neuromuscular blockade. Cephalosporins may add to renal injury, and reduced kidney function would raise plazomicin exposure.
What this interaction means in plain words
Cefpodoxime and Plazomicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefpodoxime belongs to Anti Bacterial; Plazomicin belongs to Anti Bacterial.
Why it happens
Additive nephrotoxicity, with possible reduced aminoglycoside clearance if renal function declines.
What to do
Monitor serum creatinine and plazomicin concentrations, and ask about hearing changes or tinnitus. Adjust the plazomicin dose to renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cefpodoxime
- Aluminum hydroxide + Cefpodoxime Moderate
- Amikacin + Cefpodoxime Moderate
- Calcium carbonate + Cefpodoxime Moderate
- Calcium + Cefpodoxime Moderate
- Cefpodoxime + Cholera vaccine Moderate
- Cefpodoxime + Cimetidine Moderate
Other interactions of Plazomicin
- Cefaclor + Plazomicin Moderate
- Cefadroxil + Plazomicin Moderate
- Cefalexin + Plazomicin Moderate
- Cefazolin + Plazomicin Moderate
- Cefditoren + Plazomicin Moderate
- Cefepime + Plazomicin Moderate
Frequently asked questions
Can I take Cefpodoxime with Plazomicin?
MediHelp rates the interaction as moderate. Cefpodoxime and Plazomicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Plazomicin carries warnings for nephrotoxicity, ototoxicity and neuromuscular blockade. Cephalosporins may add to renal injury, and reduced kidney function would raise plazomicin exposure.
How serious is the interaction between Cefpodoxime and Plazomicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and plazomicin concentrations, and ask about hearing changes or tinnitus. Adjust the plazomicin dose to renal function.
What other medicines interact with Cefpodoxime?
MediHelp also lists interactions of Cefpodoxime with, for example, Aluminum hydroxide, Amikacin, Calcium carbonate. The full list is on the Cefpodoxime page.
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