Drug interactions
Celecoxib + Chlorpromazine
Severity: Minor
Celecoxib and Chlorpromazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Celecoxib may modestly increase chlorpromazine levels through CYP2D6 inhibition. Clinical significance is expected to be low but could add to sedation or hypotension.
What this interaction means in plain words
Celecoxib and Chlorpromazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Celecoxib belongs to Musculoskeletal; Chlorpromazine belongs to Central Nervous System.
Why it happens
Celecoxib weakly inhibits CYP2D6, which metabolizes chlorpromazine.
What to do
No routine adjustment; monitor for sedation, orthostatic hypotension or extrapyramidal effects after celecoxib is started.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Celecoxib with Chlorpromazine?
MediHelp rates the interaction as minor. Celecoxib and Chlorpromazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Celecoxib may modestly increase chlorpromazine levels through CYP2D6 inhibition. Clinical significance is expected to be low but could add to sedation or hypotension.
How serious is the interaction between Celecoxib and Chlorpromazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment; monitor for sedation, orthostatic hypotension or extrapyramidal effects after celecoxib is started.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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