Drug interactions
Celecoxib + Ticlopidine
Severity: Moderate
Celecoxib and Ticlopidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticlopidine inhibits CYP2C9 (and CYP2C19), the main pathway for celecoxib clearance, so celecoxib exposure may increase. This could raise the likelihood of dose-related NSAID adverse effects such as gastrointestinal, renal or cardiovascular events. The combination also adds bleeding risk because ticlopidine impairs platelet function.
What this interaction means in plain words
Celecoxib and Ticlopidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Ticlopidine belongs to Cardiovascular.
Why it happens
Ticlopidine inhibits CYP2C9-mediated metabolism of celecoxib, and both drugs have additive effects on bleeding risk.
What to do
Use the lowest effective celecoxib dose and monitor for GI bleeding and other NSAID toxicity. Consider an alternative analgesic if the patient has high bleeding risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Ticlopidine
Frequently asked questions
Can I take Celecoxib with Ticlopidine?
MediHelp rates the interaction as moderate. Celecoxib and Ticlopidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ticlopidine inhibits CYP2C9 (and CYP2C19), the main pathway for celecoxib clearance, so celecoxib exposure may increase. This could raise the likelihood of dose-related NSAID adverse effects such as gastrointestinal, renal or cardiovascular events. The combination also adds bleeding risk because ticlopidine impairs platelet function.
How serious is the interaction between Celecoxib and Ticlopidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective celecoxib dose and monitor for GI bleeding and other NSAID toxicity. Consider an alternative analgesic if the patient has high bleeding risk.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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