Drug interactions
Ceritinib + Desflurane
Severity: Moderate
Ceritinib and Desflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib can prolong the QT interval and slow the heart rate. Desflurane adds QT prolongation, which may raise the risk of torsades de pointes.
What this interaction means in plain words
Ceritinib and Desflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ceritinib belongs to Oncology; Desflurane belongs to Central Nervous System.
Why it happens
Additive QT prolongation through delayed cardiac repolarization.
What to do
Check a baseline ECG and correct potassium and magnesium before anesthesia. Monitor the ECG and heart rate perioperatively.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desflurane
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Desflurane?
MediHelp rates the interaction as moderate. Ceritinib and Desflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceritinib can prolong the QT interval and slow the heart rate. Desflurane adds QT prolongation, which may raise the risk of torsades de pointes.
How serious is the interaction between Ceritinib and Desflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and correct potassium and magnesium before anesthesia. Monitor the ECG and heart rate perioperatively.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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