Drug interactions
Ceritinib + Ethinyl estradiol-drospirenone
Severity: Minor
Ceritinib and Ethinyl estradiol-drospirenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib inhibits CYP3A4 and could raise ethinyl estradiol exposure, although the effect on a contraceptive is likely small. Ceritinib is also embryotoxic, so reliable contraception is required during therapy.
What this interaction means in plain words
Ceritinib and Ethinyl estradiol-drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ceritinib belongs to Oncology; Ethinyl estradiol-drospirenone belongs to Endocrine.
Why it happens
Ceritinib inhibits CYP3A4, which may reduce the metabolism of ethinyl estradiol.
What to do
Continue contraception as required during ceritinib therapy, adding a barrier method per labeling. Watch for estrogen-related adverse effects such as nausea or breast tenderness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Ethinyl estradiol-drospirenone?
MediHelp rates the interaction as minor. Ceritinib and Ethinyl estradiol-drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ceritinib inhibits CYP3A4 and could raise ethinyl estradiol exposure, although the effect on a contraceptive is likely small. Ceritinib is also embryotoxic, so reliable contraception is required during therapy.
How serious is the interaction between Ceritinib and Ethinyl estradiol-drospirenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Continue contraception as required during ceritinib therapy, adding a barrier method per labeling. Watch for estrogen-related adverse effects such as nausea or breast tenderness.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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