Drug interactions
Ceritinib + Omeprazole
Severity: Moderate
Ceritinib and Omeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib solubility falls as gastric pH rises, so acid suppression may lower its exposure. The effect is less marked when ceritinib is taken with food.
What this interaction means in plain words
Ceritinib and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ceritinib belongs to Oncology; Omeprazole belongs to Gastrointestinal Tract.
Why it happens
Increased gastric pH reduces ceritinib solubility and absorption.
What to do
Consider an alternative to the PPI. If a PPI is required, take ceritinib with food and monitor for reduced efficacy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Omeprazole?
MediHelp rates the interaction as moderate. Ceritinib and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceritinib solubility falls as gastric pH rises, so acid suppression may lower its exposure. The effect is less marked when ceritinib is taken with food.
How serious is the interaction between Ceritinib and Omeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative to the PPI. If a PPI is required, take ceritinib with food and monitor for reduced efficacy.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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