Drug interactions
Ceritinib + Rivaroxaban
Severity: Moderate
Ceritinib and Rivaroxaban: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib is a strong CYP3A4 inhibitor and also inhibits P-glycoprotein, so it may increase rivaroxaban concentrations. This could raise bleeding risk, although no specific interaction study is available.
What this interaction means in plain words
Ceritinib and Rivaroxaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ceritinib belongs to Oncology; Rivaroxaban belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4 and possibly P-glycoprotein, reducing rivaroxaban clearance.
What to do
Monitor closely for bleeding and consider an alternative anticoagulant, especially in renal impairment. Reassess the need for rivaroxaban if signs of bleeding appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rivaroxaban
- Defibrotide + Rivaroxaban Contraindicated
- Ketoconazole + Rivaroxaban Contraindicated
- Ketorolac + Rivaroxaban Contraindicated
- Abciximab + Rivaroxaban Major
- Acalabrutinib + Rivaroxaban Major
- Acetylsalicylic acid + Rivaroxaban Major
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Rivaroxaban?
MediHelp rates the interaction as moderate. Ceritinib and Rivaroxaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceritinib is a strong CYP3A4 inhibitor and also inhibits P-glycoprotein, so it may increase rivaroxaban concentrations. This could raise bleeding risk, although no specific interaction study is available.
How serious is the interaction between Ceritinib and Rivaroxaban?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for bleeding and consider an alternative anticoagulant, especially in renal impairment. Reassess the need for rivaroxaban if signs of bleeding appear.
What other medicines interact with Rivaroxaban?
MediHelp also lists interactions of Rivaroxaban with, for example, Defibrotide, Ketoconazole, Ketorolac. The full list is on the Rivaroxaban page.
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