Drug interactions
Ceritinib + Voriconazole
Severity: Major
Ceritinib and Voriconazole: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole increases ceritinib exposure via CYP3A4 inhibition, and ceritinib may in turn modestly affect voriconazole metabolism. Both drugs prolong the QT interval, so arrhythmia risk is raised, along with ceritinib hepatic and gastrointestinal toxicity.
What this interaction means in plain words
Ceritinib and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ceritinib belongs to Oncology; Voriconazole belongs to Anti Fungals.
Why it happens
CYP3A4 inhibition raising ceritinib levels, with additive QTc prolongation.
What to do
Avoid if possible; if needed, reduce ceritinib dose by about one-third and monitor ECG, electrolytes and liver tests. Return to the previous dose after voriconazole is discontinued.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Voriconazole?
MediHelp rates the interaction as major. Ceritinib and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voriconazole increases ceritinib exposure via CYP3A4 inhibition, and ceritinib may in turn modestly affect voriconazole metabolism. Both drugs prolong the QT interval, so arrhythmia risk is raised, along with ceritinib hepatic and gastrointestinal toxicity.
How serious is the interaction between Ceritinib and Voriconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if needed, reduce ceritinib dose by about one-third and monitor ECG, electrolytes and liver tests. Return to the previous dose after voriconazole is discontinued.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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