Drug interactions
Cetirizine + Eliglustat
Severity: Minor
Cetirizine and Eliglustat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat inhibits P-glycoprotein, which may modestly raise cetirizine exposure. The clinical consequence is likely small, mainly increased drowsiness.
What this interaction means in plain words
Cetirizine and Eliglustat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cetirizine belongs to Respiratory; Eliglustat belongs to Miscellaneous.
Why it happens
Eliglustat inhibition of intestinal and renal P-glycoprotein efflux of cetirizine.
What to do
Monitor for increased drowsiness and consider a lower cetirizine dose if symptoms occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cetirizine
- Acrivastine + Cetirizine Moderate
- Amisulpride + Cetirizine Moderate
- Asenapine + Cetirizine Moderate
- Avapritinib + Cetirizine Moderate
- Benzhydrocodone / acetaminophen + Cetirizine Moderate
- Brexpiprazole + Cetirizine Moderate
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Cetirizine with Eliglustat?
MediHelp rates the interaction as minor. Cetirizine and Eliglustat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eliglustat inhibits P-glycoprotein, which may modestly raise cetirizine exposure. The clinical consequence is likely small, mainly increased drowsiness.
How serious is the interaction between Cetirizine and Eliglustat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased drowsiness and consider a lower cetirizine dose if symptoms occur.
What other medicines interact with Cetirizine?
MediHelp also lists interactions of Cetirizine with, for example, Acrivastine, Amisulpride, Asenapine. The full list is on the Cetirizine page.
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