Drug interactions
Cetirizine + Lasmiditan
Severity: Minor
Cetirizine and Lasmiditan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan inhibits P-glycoprotein in the gut and may increase cetirizine exposure. Because cetirizine has a wide safety margin, the main consequence is possible increased drowsiness. Lasmiditan itself also causes dizziness and sedation.
What this interaction means in plain words
Cetirizine and Lasmiditan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cetirizine belongs to Respiratory; Lasmiditan belongs to Central Nervous System.
Why it happens
Intestinal P-glycoprotein inhibition by lasmiditan increases cetirizine absorption.
What to do
No dose change is usually needed. Monitor for added sedation and advise against driving for at least 8 hours after lasmiditan.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cetirizine
- Acrivastine + Cetirizine Moderate
- Amisulpride + Cetirizine Moderate
- Asenapine + Cetirizine Moderate
- Avapritinib + Cetirizine Moderate
- Benzhydrocodone / acetaminophen + Cetirizine Moderate
- Brexpiprazole + Cetirizine Moderate
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Cetirizine with Lasmiditan?
MediHelp rates the interaction as minor. Cetirizine and Lasmiditan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lasmiditan inhibits P-glycoprotein in the gut and may increase cetirizine exposure. Because cetirizine has a wide safety margin, the main consequence is possible increased drowsiness. Lasmiditan itself also causes dizziness and sedation.
How serious is the interaction between Cetirizine and Lasmiditan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Monitor for added sedation and advise against driving for at least 8 hours after lasmiditan.
What other medicines interact with Cetirizine?
MediHelp also lists interactions of Cetirizine with, for example, Acrivastine, Amisulpride, Asenapine. The full list is on the Cetirizine page.
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