Drug interactions
Cetirizine + Lomitapide
Severity: Minor
Cetirizine and Lomitapide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomitapide inhibits P-glycoprotein, and cetirizine is a P-gp substrate, so cetirizine exposure could rise modestly. Because cetirizine has a wide safety margin, any effect is likely small, mainly increased drowsiness.
What this interaction means in plain words
Cetirizine and Lomitapide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cetirizine belongs to Respiratory; Lomitapide belongs to Cardiovascular.
Why it happens
Inhibition of P-glycoprotein efflux by lomitapide may increase cetirizine absorption and reduce its clearance.
What to do
No dose change is usually needed; monitor for increased drowsiness. Consider a lower cetirizine dose or a non-P-gp substrate antihistamine if sedation occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cetirizine and Lomitapide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cetirizine
- Acrivastine + Cetirizine Moderate
- Amisulpride + Cetirizine Moderate
- Asenapine + Cetirizine Moderate
- Avapritinib + Cetirizine Moderate
- Benzhydrocodone / acetaminophen + Cetirizine Moderate
- Brexpiprazole + Cetirizine Moderate
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Cetirizine with Lomitapide?
MediHelp rates the interaction as minor. Cetirizine and Lomitapide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lomitapide inhibits P-glycoprotein, and cetirizine is a P-gp substrate, so cetirizine exposure could rise modestly. Because cetirizine has a wide safety margin, any effect is likely small, mainly increased drowsiness.
How serious is the interaction between Cetirizine and Lomitapide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor for increased drowsiness. Consider a lower cetirizine dose or a non-P-gp substrate antihistamine if sedation occurs.
What other medicines interact with Cetirizine?
MediHelp also lists interactions of Cetirizine with, for example, Acrivastine, Amisulpride, Asenapine. The full list is on the Cetirizine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
