Drug interactions
Cetirizine + Vemurafenib
Severity: Minor
Cetirizine and Vemurafenib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vemurafenib inhibits P-glycoprotein and may modestly increase cetirizine exposure. Clinically this would mainly mean more drowsiness.
What this interaction means in plain words
Cetirizine and Vemurafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cetirizine belongs to Respiratory; Vemurafenib belongs to Oncology.
Why it happens
Vemurafenib inhibits P-gp-mediated efflux of cetirizine.
What to do
Monitor for sedation and reduce the cetirizine dose if adverse effects occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cetirizine
- Acrivastine + Cetirizine Moderate
- Amisulpride + Cetirizine Moderate
- Asenapine + Cetirizine Moderate
- Avapritinib + Cetirizine Moderate
- Benzhydrocodone / acetaminophen + Cetirizine Moderate
- Brexpiprazole + Cetirizine Moderate
Other interactions of Vemurafenib
Frequently asked questions
Can I take Cetirizine with Vemurafenib?
MediHelp rates the interaction as minor. Cetirizine and Vemurafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vemurafenib inhibits P-glycoprotein and may modestly increase cetirizine exposure. Clinically this would mainly mean more drowsiness.
How serious is the interaction between Cetirizine and Vemurafenib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and reduce the cetirizine dose if adverse effects occur.
What other medicines interact with Cetirizine?
MediHelp also lists interactions of Cetirizine with, for example, Acrivastine, Amisulpride, Asenapine. The full list is on the Cetirizine page.
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