Drug interactions
Chenodiol + Colestipol
Severity: Moderate
Chenodiol and Colestipol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Colestipol can bind chenodiol in the gut and reduce its absorption. This can reduce the gallstone-dissolving effect of chenodiol.
What this interaction means in plain words
Chenodiol and Colestipol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chenodiol belongs to Gastrointestinal Tract; Colestipol belongs to Cardiovascular.
Why it happens
Bile acid sequestrants adsorb chenodiol in the intestinal lumen, decreasing its absorption.
What to do
Avoid concurrent use where possible. If both are needed, give chenodiol at least 1 hour before or 4 hours after colestipol, and monitor therapeutic response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chenodiol
- Aluminum hydroxide + Chenodiol Moderate
- Calcium carbonate + Chenodiol Moderate
- Calcium + Chenodiol Moderate
- Chenodiol + Cholestyramine Moderate
- Chenodiol + Colesevelam Moderate
- Chenodiol + Warfarin Moderate
Other interactions of Colestipol
- Amlodipine-hydrochlorothiazide-valsartan + Colestipol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Colestipol Moderate
- Atenolol-chlorthalidone + Colestipol Moderate
- Azilsartan-chlorthalidone + Colestipol Moderate
- Candesartan-hydrochlorothiazide + Colestipol Moderate
- Captopril-hydrochlorothiazide + Colestipol Moderate
Frequently asked questions
Can I take Chenodiol with Colestipol?
MediHelp rates the interaction as moderate. Chenodiol and Colestipol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Colestipol can bind chenodiol in the gut and reduce its absorption. This can reduce the gallstone-dissolving effect of chenodiol.
How serious is the interaction between Chenodiol and Colestipol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible. If both are needed, give chenodiol at least 1 hour before or 4 hours after colestipol, and monitor therapeutic response.
What other medicines interact with Chenodiol?
MediHelp also lists interactions of Chenodiol with, for example, Aluminum hydroxide, Calcium carbonate, Calcium. The full list is on the Chenodiol page.
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