Drug interactions
Calcium carbonate + Chenodiol
Severity: Moderate
Calcium carbonate and Chenodiol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antacids may reduce the absorption of oral chenodiol, which could weaken gallstone dissolution or treatment effect. The effect is predicted rather than well quantified.
What this interaction means in plain words
Calcium carbonate and Chenodiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium carbonate belongs to Gastrointestinal Tract; Chenodiol belongs to Gastrointestinal Tract.
Why it happens
Antacid components may adsorb or bind bile acids in the gut, reducing absorption of chenodiol.
What to do
Separate administration by at least 2 hours. Monitor treatment response, such as gallstone imaging or symptom control.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium carbonate
Other interactions of Chenodiol
- Aluminum hydroxide + Chenodiol Moderate
- Calcium + Chenodiol Moderate
- Chenodiol + Cholestyramine Moderate
- Chenodiol + Colesevelam Moderate
- Chenodiol + Colestipol Moderate
- Chenodiol + Warfarin Moderate
Frequently asked questions
Can I take Calcium carbonate with Chenodiol?
MediHelp rates the interaction as moderate. Calcium carbonate and Chenodiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antacids may reduce the absorption of oral chenodiol, which could weaken gallstone dissolution or treatment effect. The effect is predicted rather than well quantified.
How serious is the interaction between Calcium carbonate and Chenodiol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate administration by at least 2 hours. Monitor treatment response, such as gallstone imaging or symptom control.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium carbonate page.
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