Drug interactions
Chenodiol + Warfarin
Severity: Moderate
Chenodiol and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chenodiol may alter bile acid pool and vitamin K absorption, with possible changes in warfarin response. Documentation of this interaction is limited.
What this interaction means in plain words
Chenodiol and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chenodiol belongs to Gastrointestinal Tract; Warfarin belongs to Cardiovascular.
Why it happens
Possible effect on bile acid-dependent vitamin K absorption; the mechanism is not firmly established.
What to do
Monitor INR more frequently when chenodiol is started or stopped and adjust the warfarin dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Other interactions of Chenodiol
- Aluminum hydroxide + Chenodiol Moderate
- Calcium carbonate + Chenodiol Moderate
- Calcium + Chenodiol Moderate
- Chenodiol + Cholestyramine Moderate
- Chenodiol + Colesevelam Moderate
- Chenodiol + Colestipol Moderate
Frequently asked questions
Can I take Chenodiol with Warfarin?
MediHelp rates the interaction as moderate. Chenodiol and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chenodiol may alter bile acid pool and vitamin K absorption, with possible changes in warfarin response. Documentation of this interaction is limited.
How serious is the interaction between Chenodiol and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR more frequently when chenodiol is started or stopped and adjust the warfarin dose as needed.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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