Drug interactions
Chloramphenicol + Elagolix
Severity: Moderate
Chloramphenicol and Elagolix: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol may inhibit CYP3A4 and raise elagolix levels, increasing the risk of hypoestrogenic effects such as bone loss, hot flushes and liver enzyme elevation.
What this interaction means in plain words
Chloramphenicol and Elagolix can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloramphenicol belongs to Anti Bacterial; Elagolix belongs to Musculoskeletal.
Why it happens
Inhibition of CYP3A4-mediated metabolism of elagolix.
What to do
Limit elagolix to the reduced dose and duration recommended with strong CYP3A inhibitors. Avoid prolonged co-use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Chloramphenicol with Elagolix?
MediHelp rates the interaction as moderate. Chloramphenicol and Elagolix can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol may inhibit CYP3A4 and raise elagolix levels, increasing the risk of hypoestrogenic effects such as bone loss, hot flushes and liver enzyme elevation.
How serious is the interaction between Chloramphenicol and Elagolix?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit elagolix to the reduced dose and duration recommended with strong CYP3A inhibitors. Avoid prolonged co-use.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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