Drug interactions
Chloramphenicol + Maraviroc
Severity: Moderate
Chloramphenicol and Maraviroc: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maraviroc is a CYP3A4 substrate, and inhibitors raise its exposure, which may cause postural hypotension and other dose-related adverse effects. Chloramphenicol's inhibitory strength is not well defined.
What this interaction means in plain words
Chloramphenicol and Maraviroc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloramphenicol belongs to Anti Bacterial; Maraviroc belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4-mediated maraviroc metabolism.
What to do
Monitor for postural hypotension and adverse effects, and consider reducing maraviroc to 150 mg twice daily if inhibition is clinically significant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Other interactions of Maraviroc
- Amobarbital + Maraviroc Major
- Apalutamide + Maraviroc Major
- Carbamazepine + Maraviroc Major
- Clarithromycin + Maraviroc Major
- Efavirenz + Maraviroc Major
- Enzalutamide + Maraviroc Major
Frequently asked questions
Can I take Chloramphenicol with Maraviroc?
MediHelp rates the interaction as moderate. Chloramphenicol and Maraviroc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Maraviroc is a CYP3A4 substrate, and inhibitors raise its exposure, which may cause postural hypotension and other dose-related adverse effects. Chloramphenicol's inhibitory strength is not well defined.
How serious is the interaction between Chloramphenicol and Maraviroc?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for postural hypotension and adverse effects, and consider reducing maraviroc to 150 mg twice daily if inhibition is clinically significant.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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