Drug interactions
Chloramphenicol + Progesterone
Severity: Minor
Chloramphenicol and Progesterone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol inhibits CYP3A4 and might raise progesterone concentrations. The clinical effect is likely small and short-lived given the usual short courses.
What this interaction means in plain words
Chloramphenicol and Progesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chloramphenicol belongs to Anti Bacterial; Progesterone belongs to Endocrine.
Why it happens
Chloramphenicol inhibits CYP3A4-mediated progesterone metabolism.
What to do
No dose adjustment normally needed; watch for increased progestogenic effects such as drowsiness or breast tenderness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Progesterone
Other interactions of Chloramphenicol
Frequently asked questions
Can I take Chloramphenicol with Progesterone?
MediHelp rates the interaction as minor. Chloramphenicol and Progesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chloramphenicol inhibits CYP3A4 and might raise progesterone concentrations. The clinical effect is likely small and short-lived given the usual short courses.
How serious is the interaction between Chloramphenicol and Progesterone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment normally needed; watch for increased progestogenic effects such as drowsiness or breast tenderness.
What other medicines interact with Progesterone?
MediHelp also lists interactions of Progesterone with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Progesterone page.
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