Drug interactions
Chloramphenicol + Vamorolone
Severity: Moderate
Chloramphenicol and Vamorolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol may raise vamorolone levels by inhibiting CYP3A4. Greater exposure could increase corticosteroid adverse effects such as weight gain, mood changes and adrenal suppression.
What this interaction means in plain words
Chloramphenicol and Vamorolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloramphenicol belongs to Anti Bacterial; Vamorolone belongs to Endocrine.
Why it happens
Inhibition of CYP3A4-mediated vamorolone metabolism by chloramphenicol.
What to do
Use the reduced vamorolone dose recommended with strong CYP3A4 inhibitors and monitor for corticosteroid adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Other interactions of Vamorolone
- Ketoconazole + Vamorolone Major
- Clarithromycin + Vamorolone Moderate
- Itraconazole + Vamorolone Moderate
- Mifepristone + Vamorolone Moderate
- Posaconazole + Vamorolone Moderate
- Vamorolone + Voriconazole Moderate
Frequently asked questions
Can I take Chloramphenicol with Vamorolone?
MediHelp rates the interaction as moderate. Chloramphenicol and Vamorolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol may raise vamorolone levels by inhibiting CYP3A4. Greater exposure could increase corticosteroid adverse effects such as weight gain, mood changes and adrenal suppression.
How serious is the interaction between Chloramphenicol and Vamorolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the reduced vamorolone dose recommended with strong CYP3A4 inhibitors and monitor for corticosteroid adverse effects.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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