Drug interactions
Vamorolone + Voriconazole
Severity: Moderate
Vamorolone and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole increases vamorolone exposure, which may increase corticosteroid-related adverse effects. Labeling recommends a lower dose with strong CYP3A4 inhibitors.
What this interaction means in plain words
Vamorolone and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Vamorolone belongs to Endocrine; Voriconazole belongs to Anti Fungals.
Why it happens
Strong CYP3A4 inhibition by voriconazole reduces vamorolone metabolism.
What to do
Reduce the vamorolone dose per labeling while voriconazole is used. Monitor for steroid adverse effects such as hyperglycemia, infection and adrenal suppression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Vamorolone
- Ketoconazole + Vamorolone Major
- Chloramphenicol + Vamorolone Moderate
- Clarithromycin + Vamorolone Moderate
- Itraconazole + Vamorolone Moderate
- Mifepristone + Vamorolone Moderate
- Posaconazole + Vamorolone Moderate
Frequently asked questions
Can I take Vamorolone with Voriconazole?
MediHelp rates the interaction as moderate. Vamorolone and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole increases vamorolone exposure, which may increase corticosteroid-related adverse effects. Labeling recommends a lower dose with strong CYP3A4 inhibitors.
How serious is the interaction between Vamorolone and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the vamorolone dose per labeling while voriconazole is used. Monitor for steroid adverse effects such as hyperglycemia, infection and adrenal suppression.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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