Drug interactions
Mifepristone + Vamorolone
Severity: Moderate
Mifepristone and Vamorolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4 and may raise vamorolone exposure, increasing corticosteroid adverse effects. Mifepristone also antagonizes glucocorticoid receptors, which may blunt vamorolone effect.
What this interaction means in plain words
Mifepristone and Vamorolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mifepristone belongs to Endocrine; Vamorolone belongs to Endocrine.
Why it happens
CYP3A4 inhibition reduces vamorolone metabolism; glucocorticoid receptor antagonism may oppose its effect.
What to do
Reduce the vamorolone dose per labeling for strong CYP3A4 inhibitors and monitor for corticosteroid toxicity and loss of efficacy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Mifepristone and Vamorolone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Vamorolone
- Ketoconazole + Vamorolone Major
- Chloramphenicol + Vamorolone Moderate
- Clarithromycin + Vamorolone Moderate
- Itraconazole + Vamorolone Moderate
- Posaconazole + Vamorolone Moderate
- Vamorolone + Voriconazole Moderate
Frequently asked questions
Can I take Mifepristone with Vamorolone?
MediHelp rates the interaction as moderate. Mifepristone and Vamorolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone inhibits CYP3A4 and may raise vamorolone exposure, increasing corticosteroid adverse effects. Mifepristone also antagonizes glucocorticoid receptors, which may blunt vamorolone effect.
How serious is the interaction between Mifepristone and Vamorolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the vamorolone dose per labeling for strong CYP3A4 inhibitors and monitor for corticosteroid toxicity and loss of efficacy.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
