Drug interactions
Clarithromycin + Vamorolone
Severity: Moderate
Clarithromycin and Vamorolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin, a strong CYP3A4 inhibitor, increases vamorolone exposure. This may increase corticosteroid adverse effects such as adrenal suppression, weight gain and mood change.
What this interaction means in plain words
Clarithromycin and Vamorolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clarithromycin belongs to Anti Bacterial; Vamorolone belongs to Endocrine.
Why it happens
Inhibition of CYP3A4 reduces vamorolone clearance.
What to do
Reduce the vamorolone dose per labeling when given with strong CYP3A4 inhibitors. Monitor for corticosteroid toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Vamorolone
- Ketoconazole + Vamorolone Major
- Chloramphenicol + Vamorolone Moderate
- Itraconazole + Vamorolone Moderate
- Mifepristone + Vamorolone Moderate
- Posaconazole + Vamorolone Moderate
- Vamorolone + Voriconazole Moderate
Frequently asked questions
Can I take Clarithromycin with Vamorolone?
MediHelp rates the interaction as moderate. Clarithromycin and Vamorolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clarithromycin, a strong CYP3A4 inhibitor, increases vamorolone exposure. This may increase corticosteroid adverse effects such as adrenal suppression, weight gain and mood change.
How serious is the interaction between Clarithromycin and Vamorolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the vamorolone dose per labeling when given with strong CYP3A4 inhibitors. Monitor for corticosteroid toxicity.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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