Drug interactions
Itraconazole + Vamorolone
Severity: Moderate
Itraconazole and Vamorolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole strongly inhibits CYP3A4, which metabolizes vamorolone, so vamorolone exposure rises. This can increase corticosteroid adverse effects such as adrenal suppression, weight gain, and mood changes.
What this interaction means in plain words
Itraconazole and Vamorolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Itraconazole belongs to Anti Fungals; Vamorolone belongs to Endocrine.
Why it happens
Inhibition of CYP3A4-mediated metabolism of vamorolone by itraconazole.
What to do
Reduce the vamorolone dose as directed in its labeling for strong CYP3A4 inhibitors. Monitor for corticosteroid toxicity and restore the dose after itraconazole is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Vamorolone
- Ketoconazole + Vamorolone Major
- Chloramphenicol + Vamorolone Moderate
- Clarithromycin + Vamorolone Moderate
- Mifepristone + Vamorolone Moderate
- Posaconazole + Vamorolone Moderate
- Vamorolone + Voriconazole Moderate
Frequently asked questions
Can I take Itraconazole with Vamorolone?
MediHelp rates the interaction as moderate. Itraconazole and Vamorolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole strongly inhibits CYP3A4, which metabolizes vamorolone, so vamorolone exposure rises. This can increase corticosteroid adverse effects such as adrenal suppression, weight gain, and mood changes.
How serious is the interaction between Itraconazole and Vamorolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the vamorolone dose as directed in its labeling for strong CYP3A4 inhibitors. Monitor for corticosteroid toxicity and restore the dose after itraconazole is stopped.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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