Drug interactions
Posaconazole + Vamorolone
Severity: Moderate
Posaconazole and Vamorolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole inhibits CYP3A4 and can increase vamorolone exposure. Higher levels may amplify corticosteroid adverse effects such as adrenal suppression, weight gain and infection risk.
What this interaction means in plain words
Posaconazole and Vamorolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Posaconazole belongs to Anti Fungals; Vamorolone belongs to Endocrine.
Why it happens
Inhibition of CYP3A4-mediated metabolism of vamorolone.
What to do
Reduce the vamorolone dose per labeling when given with a strong CYP3A4 inhibitor. Monitor for corticosteroid toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Vamorolone
- Ketoconazole + Vamorolone Major
- Chloramphenicol + Vamorolone Moderate
- Clarithromycin + Vamorolone Moderate
- Itraconazole + Vamorolone Moderate
- Mifepristone + Vamorolone Moderate
- Vamorolone + Voriconazole Moderate
Frequently asked questions
Can I take Posaconazole with Vamorolone?
MediHelp rates the interaction as moderate. Posaconazole and Vamorolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole inhibits CYP3A4 and can increase vamorolone exposure. Higher levels may amplify corticosteroid adverse effects such as adrenal suppression, weight gain and infection risk.
How serious is the interaction between Posaconazole and Vamorolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the vamorolone dose per labeling when given with a strong CYP3A4 inhibitor. Monitor for corticosteroid toxicity.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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