Drug interactions
Chloramphenicol + Vilazodone
Severity: Moderate
Chloramphenicol and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol may increase vilazodone exposure through CYP3A4 inhibition. This raises the risk of serotonergic and gastrointestinal adverse effects.
What this interaction means in plain words
Chloramphenicol and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloramphenicol belongs to Anti Bacterial; Vilazodone belongs to Central Nervous System.
Why it happens
CYP3A4 inhibition reduces vilazodone metabolic clearance.
What to do
Monitor for serotonin toxicity and intolerance, and consider lowering the vilazodone dose while chloramphenicol is given.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Frequently asked questions
Can I take Chloramphenicol with Vilazodone?
MediHelp rates the interaction as moderate. Chloramphenicol and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol may increase vilazodone exposure through CYP3A4 inhibition. This raises the risk of serotonergic and gastrointestinal adverse effects.
How serious is the interaction between Chloramphenicol and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin toxicity and intolerance, and consider lowering the vilazodone dose while chloramphenicol is given.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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