Drug interactions
Chlordiazepoxide-clidinium + Chlorpromazine
Severity: Moderate
Chlordiazepoxide-clidinium and Chlorpromazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine is strongly sedating and combined with a benzodiazepine can cause marked drowsiness, hypotension and psychomotor impairment. Additive anticholinergic effects with clidinium may also occur.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Chlorpromazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract; Chlorpromazine belongs to Central Nervous System.
Why it happens
Additive CNS depression and additive anticholinergic and hypotensive effects.
What to do
Monitor sedation, blood pressure and anticholinergic effects; start with low doses and adjust gradually.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Chlorpromazine?
MediHelp rates the interaction as moderate. Chlordiazepoxide-clidinium and Chlorpromazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine is strongly sedating and combined with a benzodiazepine can cause marked drowsiness, hypotension and psychomotor impairment. Additive anticholinergic effects with clidinium may also occur.
How serious is the interaction between Chlordiazepoxide-clidinium and Chlorpromazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, blood pressure and anticholinergic effects; start with low doses and adjust gradually.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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