Drug interactions
Chlordiazepoxide-clidinium + Enzalutamide
Severity: Moderate
Chlordiazepoxide-clidinium and Enzalutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide is a strong CYP3A4 inducer and can lower exposure to CYP3A4 substrates such as chlordiazepoxide. The result may be reduced sedative or anxiolytic efficacy. Induction develops over weeks and wanes slowly after stopping.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract; Enzalutamide belongs to Endocrine.
Why it happens
Enzalutamide induces CYP3A4, increasing chlordiazepoxide clearance.
What to do
Monitor clinical response and titrate chlordiazepoxide upward if needed, or use a benzodiazepine not dependent on CYP3A4 such as lorazepam. Reduce the dose again after enzalutamide is withdrawn.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Enzalutamide?
MediHelp rates the interaction as moderate. Chlordiazepoxide-clidinium and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide is a strong CYP3A4 inducer and can lower exposure to CYP3A4 substrates such as chlordiazepoxide. The result may be reduced sedative or anxiolytic efficacy. Induction develops over weeks and wanes slowly after stopping.
How serious is the interaction between Chlordiazepoxide-clidinium and Enzalutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and titrate chlordiazepoxide upward if needed, or use a benzodiazepine not dependent on CYP3A4 such as lorazepam. Reduce the dose again after enzalutamide is withdrawn.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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