Drug interactions
Chlordiazepoxide-clidinium + Perampanel
Severity: Moderate
Chlordiazepoxide-clidinium and Perampanel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perampanel causes dizziness, somnolence and impaired coordination, and these effects add to those of chlordiazepoxide. Psychomotor impairment and fall risk may increase, especially in older patients.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Perampanel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract; Perampanel belongs to Central Nervous System.
Why it happens
Additive CNS depression through different pathways (AMPA antagonism plus GABA-A potentiation).
What to do
Monitor for excessive sedation, ataxia and falls, especially during perampanel titration. Reduce the benzodiazepine dose if impairment develops and advise against driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Perampanel
- Apalutamide + Perampanel Major
- Enzalutamide + Perampanel Major
- Alprazolam + Perampanel Moderate
- Amisulpride + Perampanel Moderate
- Amobarbital + Perampanel Moderate
- Asenapine + Perampanel Moderate
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Perampanel?
MediHelp rates the interaction as moderate. Chlordiazepoxide-clidinium and Perampanel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perampanel causes dizziness, somnolence and impaired coordination, and these effects add to those of chlordiazepoxide. Psychomotor impairment and fall risk may increase, especially in older patients.
How serious is the interaction between Chlordiazepoxide-clidinium and Perampanel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation, ataxia and falls, especially during perampanel titration. Reduce the benzodiazepine dose if impairment develops and advise against driving.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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