Drug interactions
Chlordiazepoxide-clidinium + Posaconazole
Severity: Moderate
Chlordiazepoxide-clidinium and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole is a strong CYP3A4 inhibitor and can raise chlordiazepoxide concentrations, prolonging and intensifying sedation and psychomotor impairment. The effect is greater in older adults and those with liver disease.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract; Posaconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4-mediated hepatic and intestinal metabolism of chlordiazepoxide.
What to do
Monitor for excessive sedation and respiratory depression and consider reducing the chlordiazepoxide dose during posaconazole therapy. A non-CYP3A4 benzodiazepine such as lorazepam may be preferred.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Posaconazole?
MediHelp rates the interaction as moderate. Chlordiazepoxide-clidinium and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole is a strong CYP3A4 inhibitor and can raise chlordiazepoxide concentrations, prolonging and intensifying sedation and psychomotor impairment. The effect is greater in older adults and those with liver disease.
How serious is the interaction between Chlordiazepoxide-clidinium and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and respiratory depression and consider reducing the chlordiazepoxide dose during posaconazole therapy. A non-CYP3A4 benzodiazepine such as lorazepam may be preferred.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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