Drug interactions
Chlordiazepoxide-clidinium + Propofol
Severity: Major
Chlordiazepoxide-clidinium and Propofol: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzodiazepines potentiate the sedative and respiratory depressant effects of propofol, lowering the dose needed and increasing the risk of hypotension, apnea and airway obstruction.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Propofol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract; Propofol belongs to Central Nervous System.
Why it happens
Additive GABA-A receptor potentiation producing synergistic CNS and respiratory depression.
What to do
Titrate propofol cautiously with reduced doses and use continuous monitoring of oxygenation, ventilation and blood pressure. Ensure airway management capability is available.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Propofol
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Propofol?
MediHelp rates the interaction as major. Chlordiazepoxide-clidinium and Propofol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Benzodiazepines potentiate the sedative and respiratory depressant effects of propofol, lowering the dose needed and increasing the risk of hypotension, apnea and airway obstruction.
How serious is the interaction between Chlordiazepoxide-clidinium and Propofol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol cautiously with reduced doses and use continuous monitoring of oxygenation, ventilation and blood pressure. Ensure airway management capability is available.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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