Drug interactions
Chlordiazepoxide-clidinium + Tucatinib
Severity: Moderate
Chlordiazepoxide-clidinium and Tucatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib inhibits CYP3A and may raise chlordiazepoxide exposure. This can increase sedation and psychomotor impairment, though chlordiazepoxide is only partly CYP3A dependent.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract; Tucatinib belongs to Oncology.
Why it happens
Tucatinib inhibition of CYP3A4-mediated metabolism of chlordiazepoxide.
What to do
Monitor for excess sedation and consider reducing the chlordiazepoxide dose; consider a benzodiazepine with non-CYP3A clearance such as lorazepam if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Tucatinib?
MediHelp rates the interaction as moderate. Chlordiazepoxide-clidinium and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib inhibits CYP3A and may raise chlordiazepoxide exposure. This can increase sedation and psychomotor impairment, though chlordiazepoxide is only partly CYP3A dependent.
How serious is the interaction between Chlordiazepoxide-clidinium and Tucatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and consider reducing the chlordiazepoxide dose; consider a benzodiazepine with non-CYP3A clearance such as lorazepam if needed.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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