Drug interactions
Chloroquine + Dacomitinib
Severity: Moderate
Chloroquine and Dacomitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dacomitinib strongly inhibits CYP2D6, which contributes to chloroquine metabolism. Chloroquine exposure may rise, increasing the risk of adverse effects including QT prolongation.
What this interaction means in plain words
Chloroquine and Dacomitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloroquine belongs to Anti Parasitic; Dacomitinib belongs to Oncology.
Why it happens
Dacomitinib inhibits CYP2D6, reducing chloroquine metabolism.
What to do
Monitor for chloroquine toxicity and consider an ECG in patients with cardiac risk factors. Use short courses where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Other interactions of Dacomitinib
- Dacomitinib + Thioridazine Contraindicated
- Amitriptyline + Dacomitinib Major
- Atomoxetine + Dacomitinib Major
- Brexpiprazole + Dacomitinib Major
- Clomipramine + Dacomitinib Major
- Dacomitinib + Desipramine Major
Frequently asked questions
Can I take Chloroquine with Dacomitinib?
MediHelp rates the interaction as moderate. Chloroquine and Dacomitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dacomitinib strongly inhibits CYP2D6, which contributes to chloroquine metabolism. Chloroquine exposure may rise, increasing the risk of adverse effects including QT prolongation.
How serious is the interaction between Chloroquine and Dacomitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for chloroquine toxicity and consider an ECG in patients with cardiac risk factors. Use short courses where possible.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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