Drug interactions
Chloroquine + Desflurane
Severity: Moderate
Chloroquine and Desflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both can prolong the QT interval, so chloroquine in the perioperative period may increase the risk of arrhythmia during desflurane anesthesia.
What this interaction means in plain words
Chloroquine and Desflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloroquine belongs to Anti Parasitic; Desflurane belongs to Central Nervous System.
Why it happens
Additive QT prolongation.
What to do
Review the preoperative ECG and electrolytes, and monitor ECG continuously during anesthesia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Other interactions of Desflurane
Frequently asked questions
Can I take Chloroquine with Desflurane?
MediHelp rates the interaction as moderate. Chloroquine and Desflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both can prolong the QT interval, so chloroquine in the perioperative period may increase the risk of arrhythmia during desflurane anesthesia.
How serious is the interaction between Chloroquine and Desflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review the preoperative ECG and electrolytes, and monitor ECG continuously during anesthesia.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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