Drug interactions
Chloroquine + Eliglustat
Severity: Major
Chloroquine and Eliglustat: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloroquine inhibits CYP2D6 and can raise eliglustat concentrations, which prolongs PR, QRS and QT intervals and may provoke arrhythmias. Chloroquine itself also prolongs the QT interval.
What this interaction means in plain words
Chloroquine and Eliglustat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chloroquine belongs to Anti Parasitic; Eliglustat belongs to Miscellaneous.
Why it happens
Inhibition of CYP2D6-mediated eliglustat metabolism with additive QT effects.
What to do
Avoid if possible; if used, reduce the eliglustat dose per labeling for CYP2D6 inhibitors and monitor ECG.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Chloroquine with Eliglustat?
MediHelp rates the interaction as major. Chloroquine and Eliglustat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Chloroquine inhibits CYP2D6 and can raise eliglustat concentrations, which prolongs PR, QRS and QT intervals and may provoke arrhythmias. Chloroquine itself also prolongs the QT interval.
How serious is the interaction between Chloroquine and Eliglustat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if used, reduce the eliglustat dose per labeling for CYP2D6 inhibitors and monitor ECG.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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