Drug interactions
Chloroquine + Iloperidone
Severity: Major
Chloroquine and Iloperidone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloroquine inhibits CYP2D6, raising iloperidone levels, while iloperidone may weakly inhibit CYP3A4 and raise chloroquine levels. Both drugs prolong the QT interval, so the combination raises the risk of arrhythmia.
What this interaction means in plain words
Chloroquine and Iloperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chloroquine belongs to Anti Parasitic; Iloperidone belongs to Central Nervous System.
Why it happens
Additive QT prolongation plus CYP2D6 inhibition by chloroquine and CYP3A4 inhibition by iloperidone.
What to do
Avoid the combination where possible. If unavoidable, monitor ECG and electrolytes and consider reducing the iloperidone dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Chloroquine with Iloperidone?
MediHelp rates the interaction as major. Chloroquine and Iloperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Chloroquine inhibits CYP2D6, raising iloperidone levels, while iloperidone may weakly inhibit CYP3A4 and raise chloroquine levels. Both drugs prolong the QT interval, so the combination raises the risk of arrhythmia.
How serious is the interaction between Chloroquine and Iloperidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If unavoidable, monitor ECG and electrolytes and consider reducing the iloperidone dose.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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