Drug interactions
Chloroquine + Metoprolol
Severity: Moderate
Chloroquine and Metoprolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloroquine inhibits CYP2D6, the main pathway for metoprolol clearance, which can raise metoprolol levels. This may cause excessive bradycardia and hypotension.
What this interaction means in plain words
Chloroquine and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloroquine belongs to Anti Parasitic; Metoprolol belongs to Cardiovascular.
Why it happens
Chloroquine inhibits CYP2D6-mediated metoprolol metabolism.
What to do
Monitor heart rate and blood pressure after starting or stopping chloroquine. Lower the metoprolol dose if bradycardia or hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Frequently asked questions
Can I take Chloroquine with Metoprolol?
MediHelp rates the interaction as moderate. Chloroquine and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloroquine inhibits CYP2D6, the main pathway for metoprolol clearance, which can raise metoprolol levels. This may cause excessive bradycardia and hypotension.
How serious is the interaction between Chloroquine and Metoprolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure after starting or stopping chloroquine. Lower the metoprolol dose if bradycardia or hypotension occurs.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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