Drug interactions
Chloroquine + Rilpivirine
Severity: Moderate
Chloroquine and Rilpivirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rilpivirine at higher than recommended doses prolongs the QT interval, and chloroquine also prolongs QT. Combined use may add to arrhythmic risk, particularly with other risk factors.
What this interaction means in plain words
Chloroquine and Rilpivirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloroquine belongs to Anti Parasitic; Rilpivirine belongs to Anti Virals.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Obtain a baseline ECG and correct electrolyte abnormalities in patients with cardiac risk factors. Monitor the QTc during short courses of chloroquine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Other interactions of Rilpivirine
- Carbamazepine + Rilpivirine Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Efavirenz + Rilpivirine Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
Frequently asked questions
Can I take Chloroquine with Rilpivirine?
MediHelp rates the interaction as moderate. Chloroquine and Rilpivirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rilpivirine at higher than recommended doses prolongs the QT interval, and chloroquine also prolongs QT. Combined use may add to arrhythmic risk, particularly with other risk factors.
How serious is the interaction between Chloroquine and Rilpivirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct electrolyte abnormalities in patients with cardiac risk factors. Monitor the QTc during short courses of chloroquine.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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