Drug interactions
Chloroquine + Tazemetostat
Severity: Minor
Chloroquine and Tazemetostat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak to moderate CYP3A4 inducer and may lower exposure to CYP3A4 substrates. Chloroquine is metabolized only in part by CYP3A4, so any reduction in its levels is likely modest and of uncertain clinical significance.
What this interaction means in plain words
Chloroquine and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chloroquine belongs to Anti Parasitic; Tazemetostat belongs to Miscellaneous.
Why it happens
Induction of CYP3A4 by tazemetostat may modestly increase chloroquine clearance.
What to do
No routine dose change is needed. Watch for reduced efficacy of chloroquine, particularly when it is used for malaria treatment or prophylaxis.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Other interactions of Tazemetostat
Frequently asked questions
Can I take Chloroquine with Tazemetostat?
MediHelp rates the interaction as minor. Chloroquine and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tazemetostat is a weak to moderate CYP3A4 inducer and may lower exposure to CYP3A4 substrates. Chloroquine is metabolized only in part by CYP3A4, so any reduction in its levels is likely modest and of uncertain clinical significance.
How serious is the interaction between Chloroquine and Tazemetostat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Watch for reduced efficacy of chloroquine, particularly when it is used for malaria treatment or prophylaxis.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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