Drug interactions
Chloroquine + Vorinostat
Severity: Moderate
Chloroquine and Vorinostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both chloroquine and vorinostat have been associated with QTc prolongation. Together they may raise the risk of ventricular arrhythmias including torsades de pointes.
What this interaction means in plain words
Chloroquine and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloroquine belongs to Anti Parasitic; Vorinostat belongs to Oncology.
Why it happens
Additive QT prolongation through effects on cardiac repolarization.
What to do
Monitor the ECG and keep potassium and magnesium within normal range during co-administration. Avoid combining in patients with a prolonged baseline QTc.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Other interactions of Vorinostat
- Thioridazine + Vorinostat Contraindicated
- Amiodarone + Vorinostat Major
- Amisulpride + Vorinostat Major
- Anagrelide + Vorinostat Major
- Asenapine + Vorinostat Major
- Chlorpromazine + Vorinostat Major
Frequently asked questions
Can I take Chloroquine with Vorinostat?
MediHelp rates the interaction as moderate. Chloroquine and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both chloroquine and vorinostat have been associated with QTc prolongation. Together they may raise the risk of ventricular arrhythmias including torsades de pointes.
How serious is the interaction between Chloroquine and Vorinostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the ECG and keep potassium and magnesium within normal range during co-administration. Avoid combining in patients with a prolonged baseline QTc.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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