Drug interactions
Chlorpheniramine + Chlorpromazine
Severity: Moderate
Chlorpheniramine and Chlorpromazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are sedating and anticholinergic. Together they may cause marked drowsiness, impaired psychomotor performance and anticholinergic effects such as dry mouth, constipation and urinary retention.
What this interaction means in plain words
Chlorpheniramine and Chlorpromazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpheniramine belongs to Respiratory; Chlorpromazine belongs to Central Nervous System.
Why it happens
Additive H1 antagonism, CNS depression and muscarinic blockade.
What to do
Prefer a non-sedating antihistamine. Warn patients about drowsiness and monitor older patients for confusion and urinary retention.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Chlorpheniramine
Frequently asked questions
Can I take Chlorpheniramine with Chlorpromazine?
MediHelp rates the interaction as moderate. Chlorpheniramine and Chlorpromazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are sedating and anticholinergic. Together they may cause marked drowsiness, impaired psychomotor performance and anticholinergic effects such as dry mouth, constipation and urinary retention.
How serious is the interaction between Chlorpheniramine and Chlorpromazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-sedating antihistamine. Warn patients about drowsiness and monitor older patients for confusion and urinary retention.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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