Drug interactions
Chlorpheniramine + Elagolix
Severity: Minor
Chlorpheniramine and Elagolix: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is a weak-to-moderate CYP3A4 inducer and may reduce chlorpheniramine exposure. Any loss of antihistamine effect is likely modest.
What this interaction means in plain words
Chlorpheniramine and Elagolix have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorpheniramine belongs to Respiratory; Elagolix belongs to Musculoskeletal.
Why it happens
Elagolix induction of CYP3A4 increases chlorpheniramine metabolism.
What to do
Monitor allergy symptom control and increase the chlorpheniramine dose only if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chlorpheniramine
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Chlorpheniramine with Elagolix?
MediHelp rates the interaction as minor. Chlorpheniramine and Elagolix have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elagolix is a weak-to-moderate CYP3A4 inducer and may reduce chlorpheniramine exposure. Any loss of antihistamine effect is likely modest.
How serious is the interaction between Chlorpheniramine and Elagolix?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor allergy symptom control and increase the chlorpheniramine dose only if needed.
What other medicines interact with Chlorpheniramine?
MediHelp also lists interactions of Chlorpheniramine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Chlorpheniramine page.
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