Drug interactions
Chlorpheniramine + Prochlorperazine
Severity: Moderate
Chlorpheniramine and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have sedative and anticholinergic properties. Together they can cause marked drowsiness, dry mouth, blurred vision, constipation and urinary retention, particularly in older adults.
What this interaction means in plain words
Chlorpheniramine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpheniramine belongs to Respiratory; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive H1-antihistaminic, anticholinergic and CNS depressant effects.
What to do
Monitor for oversedation and anticholinergic effects, and consider a non-sedating antihistamine. Warn patients against driving or operating machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Chlorpheniramine
Frequently asked questions
Can I take Chlorpheniramine with Prochlorperazine?
MediHelp rates the interaction as moderate. Chlorpheniramine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have sedative and anticholinergic properties. Together they can cause marked drowsiness, dry mouth, blurred vision, constipation and urinary retention, particularly in older adults.
How serious is the interaction between Chlorpheniramine and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and anticholinergic effects, and consider a non-sedating antihistamine. Warn patients against driving or operating machinery.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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