Drug interactions
Chlorpheniramine + Propofol
Severity: Moderate
Chlorpheniramine and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpheniramine causes sedation and may potentiate the CNS depression of propofol. Recovery may be prolonged.
What this interaction means in plain words
Chlorpheniramine and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpheniramine belongs to Respiratory; Propofol belongs to Central Nervous System.
Why it happens
Additive CNS depression from H1 antagonism and GABA-A potentiation.
What to do
Titrate propofol to effect with a possible dose reduction, and monitor sedation and ventilation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propofol
Other interactions of Chlorpheniramine
Frequently asked questions
Can I take Chlorpheniramine with Propofol?
MediHelp rates the interaction as moderate. Chlorpheniramine and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpheniramine causes sedation and may potentiate the CNS depression of propofol. Recovery may be prolonged.
How serious is the interaction between Chlorpheniramine and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol to effect with a possible dose reduction, and monitor sedation and ventilation.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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