Drug interactions
Chlorpheniramine + Tucatinib
Severity: Minor
Chlorpheniramine and Tucatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib is a moderate CYP3A inhibitor and may raise chlorpheniramine exposure, though chlorpheniramine is not a sensitive CYP3A substrate with a narrow therapeutic index. The expected result is greater sedation and anticholinergic effects.
What this interaction means in plain words
Chlorpheniramine and Tucatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorpheniramine belongs to Respiratory; Tucatinib belongs to Oncology.
Why it happens
Inhibition of CYP3A-mediated metabolism of chlorpheniramine by tucatinib.
What to do
No routine dose change is needed. Monitor for increased drowsiness or anticholinergic effects and reduce the antihistamine dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chlorpheniramine
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Chlorpheniramine with Tucatinib?
MediHelp rates the interaction as minor. Chlorpheniramine and Tucatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tucatinib is a moderate CYP3A inhibitor and may raise chlorpheniramine exposure, though chlorpheniramine is not a sensitive CYP3A substrate with a narrow therapeutic index. The expected result is greater sedation and anticholinergic effects.
How serious is the interaction between Chlorpheniramine and Tucatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for increased drowsiness or anticholinergic effects and reduce the antihistamine dose if they occur.
What other medicines interact with Chlorpheniramine?
MediHelp also lists interactions of Chlorpheniramine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Chlorpheniramine page.
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