Drug interactions
Chlorpromazine + Chlorzoxazone
Severity: Moderate
Chlorpromazine and Chlorzoxazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine is strongly sedating and, with chlorzoxazone, can produce additive drowsiness, dizziness and hypotension. The combination may impair performance and increase fall risk.
What this interaction means in plain words
Chlorpromazine and Chlorzoxazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Chlorzoxazone belongs to Musculoskeletal.
Why it happens
Additive CNS depression, with added antihistaminic and alpha-blocking effects of chlorpromazine.
What to do
Monitor sedation and blood pressure, particularly after dose changes, and consider reducing the dose of one agent. Advise caution with driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorzoxazone
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Chlorzoxazone?
MediHelp rates the interaction as moderate. Chlorpromazine and Chlorzoxazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine is strongly sedating and, with chlorzoxazone, can produce additive drowsiness, dizziness and hypotension. The combination may impair performance and increase fall risk.
How serious is the interaction between Chlorpromazine and Chlorzoxazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure, particularly after dose changes, and consider reducing the dose of one agent. Advise caution with driving and alcohol.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
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