Drug interactions
Chlorpromazine + Cyclizine
Severity: Moderate
Chlorpromazine and Cyclizine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclizine is a sedating anticholinergic antihistamine, so combining it with chlorpromazine adds to drowsiness and anticholinergic effects such as dry mouth, constipation, urinary retention and confusion. Older patients are particularly vulnerable.
What this interaction means in plain words
Chlorpromazine and Cyclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Cyclizine belongs to Respiratory.
Why it happens
Additive H1 blockade, CNS depression and muscarinic antagonism.
What to do
Avoid duplicating sedating antiemetics where possible. Monitor for oversedation, confusion and anticholinergic toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Chlorpromazine with Cyclizine?
MediHelp rates the interaction as moderate. Chlorpromazine and Cyclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclizine is a sedating anticholinergic antihistamine, so combining it with chlorpromazine adds to drowsiness and anticholinergic effects such as dry mouth, constipation, urinary retention and confusion. Older patients are particularly vulnerable.
How serious is the interaction between Chlorpromazine and Cyclizine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicating sedating antiemetics where possible. Monitor for oversedation, confusion and anticholinergic toxicity.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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