Drug interactions
Chlorpromazine + Dapagliflozin-metformin
Severity: Moderate
Chlorpromazine and Dapagliflozin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine, particularly at higher doses, can impair glucose tolerance and raise blood glucose, opposing the effect of the antidiabetic combination. Glucose may fall again when chlorpromazine is discontinued.
What this interaction means in plain words
Chlorpromazine and Dapagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Dapagliflozin-metformin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism, as phenothiazines can reduce insulin release and sensitivity.
What to do
Monitor blood glucose when starting or stopping chlorpromazine and adjust antidiabetic doses accordingly, watching for hypoglycemia after withdrawal.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Dapagliflozin-metformin?
MediHelp rates the interaction as moderate. Chlorpromazine and Dapagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine, particularly at higher doses, can impair glucose tolerance and raise blood glucose, opposing the effect of the antidiabetic combination. Glucose may fall again when chlorpromazine is discontinued.
How serious is the interaction between Chlorpromazine and Dapagliflozin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping chlorpromazine and adjust antidiabetic doses accordingly, watching for hypoglycemia after withdrawal.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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