Drug interactions
Chlorpromazine + Deutetrabenazine
Severity: Moderate
Chlorpromazine and Deutetrabenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine prolongs the QT interval, and deutetrabenazine has small QT effects that become relevant with other QT-prolonging drugs or risk factors. Together they may raise the risk of torsades de pointes. Both can also cause sedation and parkinsonism.
What this interaction means in plain words
Chlorpromazine and Deutetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Deutetrabenazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation; both drugs also affect dopaminergic pathways (D2 blockade and VMAT2 inhibition).
What to do
Check ECG at baseline and after dose changes, and correct hypokalemia and hypomagnesemia. Avoid the combination in patients with congenital long QT or bradycardia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Deutetrabenazine?
MediHelp rates the interaction as moderate. Chlorpromazine and Deutetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine prolongs the QT interval, and deutetrabenazine has small QT effects that become relevant with other QT-prolonging drugs or risk factors. Together they may raise the risk of torsades de pointes. Both can also cause sedation and parkinsonism.
How serious is the interaction between Chlorpromazine and Deutetrabenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG at baseline and after dose changes, and correct hypokalemia and hypomagnesemia. Avoid the combination in patients with congenital long QT or bradycardia.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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